张海元 教授

1. 智能可编程纳米药物的构筑及对肿瘤和肥胖病的治疗；

2. 工程化细胞的合成生物学构建及其在类风湿性关节炎的治疗；

3. 工程化外泌体的构建及其对慢性肺部疾病的治疗

1. Yan, J., Liu, L., Chen, Z.H., Zhao, Q., Han, X.Q., Wang, Y.J.,  Mu, Z.Z., Wang, X.B., Song, P.P., Kang, Y. Q., Lu, W.J., Guo, A.M., Sun, Q.F., Zhang, H.Y.* Spin-driven Enantioselective Regulation of Cyclooxygenase-2 Activity for Rheumatoid Arthritis Therapy via Chiral Gold Nanohelices. Nature Communications 2026, In Press

2. Kang, Y.;  Han, X.;  Zhou, S.;  Wang, X.;  Wang, Y.;  Song, P.;  Su, X.;  Qin, M.;  Qian, D.;  Meng, H.;  Yan, J.;  Pu, F.; Zhang, H.Y.*, Engineered Apoptotic Extracellular Vesicles for Programmable Regulation of Neutrophil-Macrophage-ROS Pathogenic Axis to Reconstruct Rheumatoid Arthritis Microenvironment. Advanced Materials 2026, 38 (3), e08072.

3. Yan, J.; Wang, Y.J.; Mu, Z.Z.; Han, X.Q.; Bi, L.P.; Wang, X.B.; Song, P.P.; Kang, Y.Q.; Wang, L.L; Zhang, X.Y.; Wang, Y.B.; Zhang, H.Y*. Gold Nanobipyramid-Mediated Apoptotic Camouflage of Adipocytes for Obesity Immunotherapy. Advanced Materials 2023, 35, 2207686

4. Cheng, Y.; Kong, X.P.; Chang, Y.; Gao, X.F.; Zhang, H.Y.*. Spatiotemporally Synchronous Oxygen Self-Supply and Reactive Oxygen Species Production on Z-Scheme Heterostructures for Hypoxic Tumor Therapy. Advanced Materials 2020, 32, 1908109.

5. Cheng, Y.; Chang, Y.; Feng, Y.; Jian, H.; Zhang, H.Y.*. Bismuth Sulfide Nanorods with Retractable Zinc Protoporphyrin Molecules for Suppressing Innate Antioxidant Defense System and Strengthening Phototherapeutic Effects. Advanced Materials 2019, 31, 1806808.

6. Cheng, Y.; Chang, Y.; Feng, Y.L.; Jian, H.; Tang, Z.H.; Zhang, H.Y.*. Deep-Level Defect Enhanced Photothermal Performance of Bismuth Sulfide-Gold Heterojunction Nanorods for Photothermal Therapy of Cancer Guided by Computed Tomography Imaging. Angewandte Chemie-International Edition 2018, 57, 246-251.

7. Zhang, H.Y.; Pokhrel, S.; Ji, Z.; Meng, H.; Wang, X.; Lin, S.; Chang, C.H.; Li, L.; Li, R.; Sun, B.; Wang, M.; Xia, T.; Maedler, L.; Nel, A.E.*. Pdo Doping Tunes Band-Gap Energy Levels As Well As Oxidative Stress Responses To A Co3O4 P-Type Semiconductor In Cells And The Lung. Journal of the American Chemical Society 2014, 136, 6406-6420.

8. Zhang, H.Y.; Dunphy, D.R.; Jiang, X.; Meng, H.; Sun, B.; Tarn, D.; Xue, M.; Wang, X.; Lin, S.; Ji, Z.; Garcia, F. L.; Kirk, M.L.; Xia, T.; Zink, J.I.; Nel, A.; Brinker, C.J.*. Processing Pathway Dependence Of Amorphous Silica Nanoparticle Toxicity: Colloidal Vs Pyrolytic. Journal of the American Chemical Society 2012, 134, 15790-15804.

9. Cheng, Y.;  Zhang, H.Y*; Qu, X.Q*, Electronic Band-Engineered Nanomaterials for Biosafety and Biomedical Application. Accounts of Materials Research 2021, 2 (9), 764-779.

10. Wang, X.;  Han, X.;  Yuan, H.;  Zhang, X.;  Kang, Y.;  Wang, Y.;  Song, P.;  Su, X.;  Chen, Z.;  Liang, H.;  Zheng, X.;  Yan, J.; Zhang, H.Y.*, Nebulized Inhalation of Engineered Extracellular Vesicles to Destruct Pre-metastatic Niche and Inhibit Postoperative Lung Metastasis in a Mouse Model. ACS Nano 2025, 19 (40), 35752-35769.

11. Liu, X.; Feng, Y.; Xu, G.; Chen, Y.; Luo, Y.; Song, J.; Bao, Y.; Yang, J.; Yu, C.; Li, Y.; Ye, H.; Ke, B.; Chen, B.; Hu, J.; Xu, J.; Zhang, H.Y.*; Shi, H.B*, MAPK-Targeted Drug Delivered by a pH-Sensitive MSNP Nanocarrier Synergizes with PD-1 Blockade in Melanoma without T-Cell Suppression. Advanced Functional Materials 2019, 0, 1806916.

12. Chang, Y.; Feng, Y.; Cheng, Y.; Zheng, R.; Wu, X.; Jian, H.; Zhang, D.; Tang, Z.; Wang, Z.; Hao, J.; Zhang, H.Y.*, Anisotropic Plasmonic Metal Heterostructures as Theranostic Nanosystems for Near Infrared Light-Activated Fluorescence Amplification and Phototherapy. Advanced Science 2019, 6, 1900158.

13. Feng, Y.; Cheng, Y.; Chang, Y.; Jian, H.; Zheng, R.; Wu, X.; Xu, K.; Wang, L.; Ma, X.; Li, X.; Zhang, H.Y.*, Time-staggered delivery of erlotinib and doxorubicin by gold nanocages with two smart polymers for reprogrammable release and synergistic with photothermal therapy. Biomaterials 2019, 217, 119327.

14. Chang, Y.; Cheng, Y.; Feng, Y. L.; Li, X.*; Zhang, H.Y.*, Resonance Energy Transfer-Promoted Photothermal and Photodynamic Performance of Gold- Copper Sulfide Yolk-Shell Nanoparticles for Chemophototherapy of Cancer. Nano Letters 2018, 18, 886-897.

15. Liu, N.; Li, K.; Li, X.; Chang, Y.; Feng, Y. L.; Sun, X. J.; Cheng, Y.; Wu, Z. J.*; Zhang, H. Y.*, Crystallographic Facet-Induced Toxicological Responses By Faceted Titanium Dioxide Nanocrystals. ACS Nano 2016, 10, 6062-6073.