颜姣 教授

主要从事免疫调制功能纳米材料的设计与可控制备，及在肥胖、肿瘤、关节炎、肺部感染、抗菌、无疤痕愈合等生物医学领域的应用研究。包括：

[1]功能性生物材料设计、合成与组装

[2]细胞功能改性用于代谢疾病、肿瘤、关节炎等治疗

[3]手性纳米材料对生物酶功能的调控

[4]新型抗菌纳米材料设计与制备

2016.12-2018.12    美国密歇根大学           化学工程        联培博士

2013.09-2019.06    国家纳米科学中心       物理化学        理学博士

2009.09-2013.06    湖南大学                   应用化学        理学学士

2023.11至今        广州医科大学                            教授

2020.03-2023.03   中国科学院长春应用化学研究所   特别研究助理

2020.03-2023.03   中国科学院长春应用化学研究所   博士后

2019.07-2023.09   中国科学院长春应用化学研究所   助理研究员

[1] 2023.11-2028.11，广州医科大学南山学者人才启动经费，在研

[2] 2024.01-2026.12，国家自然科学基金青年项目，脂滴靶向的仿生纳米胶束对脂肪细胞亚型的调控及肥胖治疗的研究，30万元，在研

[3] 2024.01-2026.12，吉林省科技发展计划项目/面上项目，非脂肪靶向的远端肥胖治疗口服纳米制剂的制备及机制研究，15万元，在研

[4] 2020.08-2022.09，中国博士后科学基金面上项目，免疫信号分子修饰的金纳米双锥组装结构用于肥胖症的治疗, 8万元，结题

[5] 2020.08-2022.09，吉林省博士后科研人员择优资助项目，免疫信号分子修饰的金纳米双锥组装结构用于肥胖症的治疗，5万元，结题

[6] 2021.10-2023.10, 吉林大学工程仿生教育部重点实验室开放基金项目，用于肥胖症治疗的双功能纳米组装体仿生构筑与机理研究, 5万元, 结题

[1] Jiao Yan, Yanjing Wang, Zhengzhi Mu, Xiaoqing Han, Luopeng Bi, Xingbo Wang, Panpan Song, Yaqing Kang, Lulu Wang, Xueyan Zhang, Yanbo Wang, Haiyuan Zhang*. Gold nanobipyramid-mediated apoptotic camouflage of adipocytes for obesity immunotherapy. Advanced Materials, 2023, 35, 2207686. (JCR Q1, IF: 32.086，被Advanced Materials Interfaces收录至Hot Topic: Surfaces and Interfaces，Nature Reviews Endocrinology综述论文正面引用)

[2] Jiao Yan, Wenchun Feng, Ji-Young Kim, Jun Lu, Prashant Kumar, Zhengzhi Mu, Xiaochun Wu, Xiaoming Mao, and Nicholas A. Kotov*. Self-assembly of chiral nanoparticles into semiconductor helices with tunable near-infrared optical activity. Chemistry of Materials, 2020, 32(1), 476−488. (JCR Q1, IF: 10.508，被Science、Nature、Nature Photonics、Nature Catalysis研究论文及Nature Reviews Chemistry综述论文等正面引用)

[3] Jiao Yan, Shuai Hou, Yinglu Ji, Xiaochun Wu*. Heat-enhanced symmetry breaking in dynamic gold nanorod oligomers: the importance of interface control. Nanoscale, 2016, 8(19), 10030-10034. (JCR Q1, IF: 8.307，被Nature封面论文正面引用)

[4] Jiao Yan, Yuandong Chen, Shuai Hou, Jiaqi Chen, Dejing Meng, Hui Zhang, Huizhen Fan, Yinglu Ji, Xiaochun Wu*. Fabricating chiroptical starfruit-like Au nanoparticles via interface modulation of chiral thiols. Nanoscale, 2017, 9(31), 11093-11102. (JCR Q1, IF:8.307)

[5] Haiyun Li, Jiao Yan, Dejing Meng, Rui Cai, Xinshuang Gao, Yinglu Ji, Liming Wang*, Chunying Chen*, Xiaochun Wu*. Gold nanorod-based nanoplatform catalyzes constant NO generation and protects from cardiovascular injury. ACS Nano, 2020, 14(10), 12854-12865. (JCR Q1, IF: 18.027)

[6] Xiaqing Wu, Jiao Yan, Xiaoqing Han, Runxiao Zheng, Panpan Song, Yanjing Wang, Haiyuan Zhang*. Core-shell nanomaterials engineered to reverse cancer multidrug resistance by immunotherapy and promote photo-responsive chemotherapy. Chemical Engineering Journal, 2022, 429, 132329. (JCR Q1, IF: 16.744)

[7] Jiaqi Chen, Jiao Yan, Yuandong Chen, Shuai Hou, Yinglu Ji, Xiaochun Wu*. Unique role of non-mercapto groups in thiol-pinning-mediated Ag growth on Au nanoparticles. Nano Research, 2018, 11, 614-624. (JCR Q1, IF: 10.269)

[8] Yanjing Wang, Yanlin Feng, Jiao Yan, Xiaoqing Han, Panpan Song, Yunyun Wu, Xingbo Wang, Zhengzhi Mu, Xi Li*, Haiyuan Zhang*. Spiky surface topography of heterostructured nanoparticles for programmable acceleration of multistage wound healing. Materials Today Nano, 2023, 100351. (JCR Q1, IF: 13.364)

[9] Keqiang Xu, Yan Cheng, Jiao Yan, Yanlin Feng, Runxiao Zheng, Xiaqing Wu, Yanjing Wang, Panpan Song, Haiyuan Zhang*. Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy. Nano Research, 2019, 12, 2947-2953. (JCR Q1, IF: 10.269)

[10] Xiaoqing Han, Luopeng Bi, Yunyun Wu, Jiao Yan, Xiaqing Wu, Runxiao Zheng, Yingying Sun, Hua Zhang, Zhenxin Wang, Yanbo Wang, Haiyuan Zhang*. Genetically engineered exosomes for targetedly preventing premetastatic niche formation and suppressing postoperative melanoma lung metastasis. Nano Today, 2022, 46, 101597. (JCR Q1, IF: 18.962)

[1] 颜姣，侯帅，吴晓春，一种放大金纳米棒组装体等离激元圆二色性的方法，2018-04-27，ZL201510058183.7

[2] 颜姣，侯帅，吴晓春，一种离散贵金属纳米颗粒及其制备方法，2019-03-29，ZL201610811654.1

[3] 李海芸，吴晓春，颜姣，王黎明，陈春英，一种具有一氧化氮合酶活性的贵金属纳米材料及其应用2019-08-09，ZL201710754491.2

[4] 张海元，韩晓庆，程岩，颜姣，适用于临床现场及非医疗环境下新型冠状病毒核酸检测试剂盒及其制造方法，2020-03-29，ZL202010644687.8