个人概况：

姓名：郭伟圣  性别：男

职称：教授  导师资格：硕/博士生导师

单位：广州医科大学生物医学工程学院、呼吸疾病国家重点实验室

学历：博士  毕业院校：天津大学

招生专业：生物医学工程、生物与医药

电子邮件：tjuguoweisheng@126.com

通信地址：广东省广州市番禺区新造镇新造路1号 广州医科大学番禺校区A2-517

研究方向：

微环境活性纳米载体，精确诊疗纳米药物克服疾病治疗耐受

所获奖项/荣誉：

1. l2020年广东省药理学会科技成果奖一等奖（排名第三）

2. l2019年中国科协青年人才托举工程

3. l2019年广州市高层次医学重点人才

4. l2018年广东省杰出青年医学人才

5. l2018年天津市自然科学奖一等奖（排名第七）；

6. l美国国家关节炎研究基金会2017年度会议基金；

7. l2017年浙江省“精英引领计划”创新性人才；

8. l2017年嘉兴市第二批“秀湖双百”创业计划；

9. l2017年嘉兴市“南湖百杰暨青年菁英”荣誉称号；

10. l2016、2017年度国家纳米科学中心年度考核“优秀”；

11. l欧洲第六届组织工程国际会议暨第三届再生生物医学材料国际会议旅行基金；

12. l2015年全国博士生论坛优秀墙报一等奖；

13. l国家留学基金委公派留学资格，获美国国立卫生研究院录取。

14. l2013年天津市生物工程年会“青年论坛”优秀报告奖。

指导学生获得的科研项目和奖项

1. 陈浩庭（2019级硕士生） 国家奖学金      2021

社会兼职

1. l中国生物材料学会       理事

2. l中国生物材料学会青年委员会      委员

3. l中国生物材料学会纳米生物材料分会   副秘书长

4. l中国生物材料学会再生医学分会    委员

5. l中国医药生物技术协会纳米生物技术分会  委员

6. l中国生物医学工程学会纳米医学与工程分会  青年委员

7. l广东省医师协会转化医学工作委员会   委员

8. lFrontier in Chemistry期刊（IF 5.22）  副编辑

9. lChinese Chemical Letters期刊（IF 6.78）  编委

主持科研/教学项目

1. 微环境活性纳米体系克服疾病耐药性，广东省自然科学杰出青年基金，2022-2025，100万元；

2. “精准靶向纳米药物用于急性髓系白血病的基因治疗”，广州市校联合项目（202102010106），2020-2022，20万元；

3. “电荷反转可变身智能纳米材料用于类风湿性关节炎靶向协同治疗”，广东省教育厅普通高校重点项目（2020ZDZX2001），2020.01~2022.12，15万元；

4. 中国科协青年人才托举项目，2019-2021，45万元；

5. “精准纳米药物设计与评价”，广州医科大学优青培育项目，2020-2021，40万元；

6. “pH敏感型纳米药物用于双策略协同性类风湿性关节炎的高效治疗”，2020.01~2023.12，国家自然科学基金面上项目（31971302），59万元；

7. “酸敏感型纳米药物用于JAK抑制剂靶向递送和cfDNA精准清除的协同性治疗类风湿性关节炎”，2019.10~2022.09，广东省自然科学基金面上项目（2019A1515011597），10万元；

8. “乳腺癌靶向纳米药物的可控构建及其荧光/光声可视化代谢分布研究”，©~2019.12，国家自然科学基金青年项目（81601603），18万元；

9. “Dual-modal MRI/SPECT Imaging Agents for Quantitative Analysis of Acidic Tumor Microenvironment”，2017.01~2019.12，中科院国际合作重点项目—中伊丝路科学基金项目（121D11KYSB20160066），45万元；

10. “pH响应型碳化铁纳米材料增强青蒿素抗肿瘤疗效研究”，2016.07~2017.07，中科院重点实验室开放课题（NSKF201607），2万元；

11. “高灵敏电化学免疫传感器构建及前列腺癌检测研究”，2017.01~2017.12，北京高等学校高水平人才交叉培养“实培计划”项目，12万元；

12. “反向荧光增强肉眼可辨家用肿瘤诊断试纸条的研发”，2017.08~2019.07，嘉兴市“秀湖双百”创业计划，30万元；

部分代表性第一和通讯作者论文：

1. Fangzhou Li, Jiang Ouyang, Zuqin Chen, Ziran Zhou, Julien Milon Essola, Barkat Ali, Xinyue Wu, Mengliang Zhu, Weisheng Guo*, Xing-Jie Liang*. Nanomedicines for T-cell mediated immunotherapy, Advanced Materials, 2023, DOI: 10.1002/adma.202301770, in press.

2. Fangke Zhang, Yawei Du, Jiancheng Zheng, Zhengwei Cai, Tao Ding, Pengzhen Zhuang, Ding Yang, Fangling Liao, Yu Zhang, Wu Yang, Yafang Xiao, Weiling He*, Wenguo Cui*, and Weisheng Guo*. Oral Administration of Multistage Albumin Nanomedicine Depots (MANDs) for Targeted Efficient Alleviation of Chronic Inflammatory Diseases, Advanced Functional Materials, 2023, 2211644

3. Changrong Shi, Qianyu Zhang, Yuying Yao, Fantian Zeng, Chao Du, Sureya Nijiati, Xuejun Wen, Xinyi Zhang, Hongzhang Yang, Haoting Chen, Zhide Guo, Xianzhong Zhang, Jinhao Gao, Weisheng Guo*, Xiaoyuan Chen*, Zijian Zhou*. Targeting the activity of T cells by membrane surface redox regulation for cancer theranostics, Nature Nanotechnology, 2022, Aug 12, Accepted.

4. Zili Wang, Xinquan Gu*, Bo Li, Jingjing Li, Fan Wang, Jing Sun*, Hongjie Zhang, Kai Liu*, Weisheng Guo*. Molecularly engineered protein glues with superior adhesion performance, Advanced Materials, 2022, 34 (41), 2204590.

5. Lu Liu, Cong Mao, Yuxuan Zhang, Haoting Chen, Yaming Zhang, Jinjin Wang, Chenxing Fu, Xinmiao Lan, Weiping Wang*, Xing-Jie Liang*, Weisheng Guo*, Antibody-sheltered Immunological Nanonut (AINUT) for Rheumatoid Arthritis Targeted Efficient Alleviation, Nano Today, 2022, 47, 101640.

6. Ying Tao, Xinmiao Lan, Yang Zhang, Chenxing Fu, Lu Liu,* Feng Cao,* Weisheng Guo*, Biomimetic nanomedicines for precise atherosclerosis theranostics, Acta Pharmaceutica Sinica B, 2022, Accepted.

7. Ruslan G. Tuguntaev, Abid Hussain, Chenxing Fu, Haoting Chen, Ying Tao, Yan Huang, Lu Liu,* Xing-Jie Liang,* and Weisheng Guo*. Bioimaging guided pharmaceutical evaluations of nanomedicines for clinical translations, Journal of Nanobiotechnology, 2022, 20 (1), 1-31.

8. Ying Tao, Xinmiao Lan, Yuxuan Zhang, Yafang Xiao, Jinjin Wang, Haoting Chen, Lu Liu, Xing-Jie Liang,* Weisheng Guo*. Navigations of the targeting pathway of nanomedicines towards tumor, Expert Opinion on Drug Delivery, 2022, 19(8), 985-996.

9. Lu Liu, Hongjun Li, Jinqiang Wang, Jinchao Zhang, Xing-Jie Liang,* Weisheng Guo,* Zhen Gu*. Leveraging macrophages for cancer theranostics, Advanced Drug Delivery Reviews, 2022, 114136.

10. Mengqi Xu, Cong Mao, Haoting Chen, Lu Liu, Yabin Wang, Abid Hussain, Sulei Li, Xu Zhang, Ruslan G. Tuguntaev, Xing-Jie Liang, Weisheng Guo,* Feng Cao*. Osteopontin targeted theranostic nanoprobes for laser-induced synergistic regression of vulnerable atherosclerotic plaques. Acta Pharmaceutica Sinica B, 2022, 12 (4), 2014-2028.

11. Liwei Chen, Yanfei Liu, Weisheng Guo,* Zhenbao Liu*. Light responsive nucleic acid for biomedical application, Exploration, 2022, 20210099.

12. Jing Chen, Xue Wang, Yuan Yuan, Haoting Chen, Lingpu Zhang, Haihua Xiao, Jingqi Chen, Yongxiang Zhao, Jin Chang, Weisheng Guo,* Xing-Jie Liang*. Exploiting the acquired vulnerability of cisplatin-resistant tumors with a hypoxia-amplifying DNA repair-inhibiting (HYDRI) nanomedicine, Science Advances, 2021, 7 (13), eabc5267.

13. Shengliang Li, Haoting Chen, Haile Liu, Lu Liu, Yuan Yuan, Cong Mao, Wei Zhang, Xiaodong Zhang, Weisheng Guo,* Chun-Sing Lee,* Xing-Jie Liang*. In Vivo Real-Time Pharmaceutical Evaluations of Near-Infrared II Fluorescent Nanomedicine Bound Polyethylene Glycol Ligands for Tumor Photothermal Ablation, ACS Nano, 2020, 14, 10, 13681–13690.

14. Xianlei Li, Haoting Chen, Cong Mao, Xing-Jie Liang,* Yan Wu,* and Weisheng Guo*. Structure Transformable Nanoparticles for Photoacoustic Imaging-Guided Photothermal Ablation of Tumors via Enzyme-Induced Multistage Delivery, Chemical Engineering Journal, 2021, 421, 127747.

15. Yingsi Xie, Ruslan G. Tuguntaev, Shixiang Wang, Bin Yang,* and Weisheng Guo*. Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy, Biophysics Reports, 2020, 6(5), 193-210.

16. Ya-Fang Xiao, Chenyang Xiang, Shengliang Li,* Cong Mao, Haoting Chen, Jia-Xiong Chen, Shuang Tian, Xiao Cui, Yingpeng Wan, Zhongming Huang, Xiaozhen Li, Xiao-Hong Zhang, Weisheng Guo,* and Chun-Sing Lee*. Single-Photomolecular Nanotheranostics for Synergetic Near-Infrared Fluorescence and Photoacoustic Imaging-Guided Highly Effective Photothermal Ablation, Small, 2020, 2002672.

17. Chenyang Xiang, Yuxuan Zhang, Weisheng Guo,* Xing-Jie Liang*. Biomimetic Carbon Nanotubes for Neurological Disease Therapeutics as Inherent Medication. Acta Pharmaceutica Sinica B, 2020, 10(2), 239-248.

18. Xiaozhen Li, Lu Liu, Shengliang Li, Yingpeng Wan, Jia-Xiong Chen, Shuang Tian, Zhongming Huang, Ya-Fang Xiao, Xiao Cui, Chengyang Xiang, Xiao-hong Zhang, Weisheng Guo,* and Chun-Sing Lee*. Biodegradable π-Conjugated Oligomer Nanoparticles with Record-High Photothermal Conversion Efficiency for Cancer Theranostics, ACS Nano, 2019, 13 (11), 12901.

19. Guangchao Qing, Xianxian Zhao, Ningqiang Gong, Jing Chen, Xianlei Li, Yaling Gan, Yongchao Wang, Zhen Zhang, Yuxuan Zhang, Weisheng Guo,* Yang Luo,* and Xing-Jie Liang*. Thermo-responsive triple-function nanotransporter for efficient chemo-photothermal therapy of multidrug-resistant bacterial infection. Nature Communications, 2019, 10 (1), 4336.

20. Weisheng Guo,* Lu Liu, Chengyang Xiang, Jingqi Chen, Xing-Jie Liang*. Engineered nanoparticles circumvent the adaptive treatment tolerance to immune-checkpoint blockade therapy. Science-China Chemistry, 2019, 12, 1557–1560.

21. Lu Liu, Fanlei Hu, Hui Wang, Xiaoli Wu, Ahmed Shaker Eltahan, Stephanie Stanford, Nunzio Bottini, Haihua Xiao, Massimo Bottini, Weisheng Guo,* Xing-Jie Liang*. Secreted Protein Acidic and Rich in Cysteine Mediated Biomimetic Delivery of Methotrexate by Albumin-Based Nanomedicines for Rheumatoid Arthritis Therapy. ACS Nano, 2019, 13, 5036-5048. （中华医学会高影响力论文）

22. Xianlei Li, Massimo Bottini, Luyao Zhang, Shuai Zhang, Jing Chen, Nicola Rosato, Xibo Ma, Yan Wu, Weisheng Guo,* and Xing-Jie Liang*. Core-Satellite Nanomedicines for In Vivo Real-Time Monitoring of Enzyme-Activatable Drug Release by Fluorescence and Photoacoustic Dual-Modal Imaging. ACS Nano, 2019, 13 (1), 176–186.

23. Tingbin Zhang, Yuanyu Huang, Xiaowei Ma, Ningqiang Gong, Xiaoxia Ye, Bo Hu, Chunhui Li, Jian-Hua Tian, Andrea Magrini, Jinchao Zhang, Weisheng Guo,* and Xing-Jie Liang*. Fluorinated Oligoethylenimine Nanoassemblies for Efficient siRNAMediated Gene Silencing in Serum-Containing Media by Effective Endosomal Escape, Nano Letters, 2018, 18, 6301-6311.

24. Jing Chen, Lu Liu, Seyed Mohammad Motevalli, Xiaoli Wu, Xiao-Hong Yang, Xianlei Li, Lu Han, Andrea Magrini, Jin Chang,* Massimo Bottini, Weisheng Guo,* and Xing-Jie Liang*. Light-Triggered Retention and Cascaded Therapy of Albumin-Based Theranostic Nanomedicines to Alleviate Tumor Adaptive Treatment Tolerance, Advanced Functional Materials, 2018, 28, 1707291.

25. Guoxian Lv,^# Weisheng Guo,^#,* Wei Zhang, Tingbin Zhang, Shuyi Li, Shizhu Chen, Ahmed Shaker Eltahan, Dongliang Wang, Jin Chang,* and Xing-Jie Liang*. Near-Infrared Emission CuInS/ZnS Quantum Dots: All-in-One Theranostic Nanomedicines With Intrinsic Fluorescence/Photoacoustic Imaging for Tumor Phototherapy, ACS Nano, 2016, 10(10): 9637.

26. Weisheng Guo, Xiaolian Sun,* Orit Jacobson, Xuefeng Yan, Kyunghyun Min, Avinash Srivatsan, Gang Niu, Dale O Kiesewetter, Jin Chang,* and Xiaoyuan Chen*. Intrinsically radioactive [64Cu] CuInS/ZnS quantum dots for PET and optical imaging: Improved radiochemical stability and controllable Cerenkov luminescence, ACS Nano, 2015, 9(1): 488-495.

27. Weitao Yang,^# Weisheng Guo,^# Wenjun Le, Guoxian Lv, Fuhe Zhang, Lei Shi, Xiuli Wang, Jun Wang, Sheng Wang, Jin Chang,* and Bingbo Zhang*. Albumin-Bioinspired Gd:CuS Nanotheranostic Agent for In Vivo Photoacoustic/Magnetic Resonance Imaging-Guided Tumor-Targeted Photothermal Therapy. ACS Nano, 2016, 10(11): 10245.

28. Shaobo Zhang,^# Weisheng Guo,^# Jie Wei, Chan Li, Xing-Jie Liang,* and Meizhen Yin*. Terrylenediimide-Based Intrinsic Theranostic Nanomedicines with High Photothermal Conversion Efficiency for Photoacoustic Imaging-Guided Cancer Therapy, ACS Nano, 2017, 11 (4), 3797.

29. Weisheng Guo,* Jing Chen, Lu Liu, Ahmed Shaker Eltahan, Nicola Rosato, Jing Yu, Dongliang Wang, Jingqi Chen, Massimo Bottini, and Xing-Jie Liang. Laser Induced Transformable BiS@HSA/DTX Multiple Nanorods for Photoacoustic/Computed Tomography Dual-Modal Imaging Guided Photothermal/Chemo Combinatorial Anticancer Therapy, ACS Appl. Mater. Interfaces, 2018, 10 (48), 41167-41177. （广州市医学会2019年优秀论文）

30. Lu Liu, Weisheng Guo*, and Xing-Jie Liang*. Move to Nano-Arthrology: Targeted Stimuli-Responsive Nanomedicines Combat Adaptive Treatment Tolerance (ATT) of Rheumatoid Arthritis, Biotechnology Journal, 2018, 1800024 (1-14).

31. Sai Ma, Seyed Mohammad Motevalli, Jiangwei Chen, Meng-Qi Xu, Yabin Wang, Jing Feng, Ya Qiu, Dong Han, Miaomiao Fan, and Weisheng Guo*, Xing-Jie Liang*, and Feng Cao*. Precise theranostic nanomedicines for inhibiting vulnerable atherosclerotic plaque progression through regulation of vascular smooth muscle cell phenotype switching, Theranostics, 2018, 8(13), 3693-3706.

32. Ahmed Shaker Eltahan, Lu Liu, Chukwunweike Ikechukwu Okeke, Min Huang, Lu Han, Jing Chen, Xue Xue, Massimo Bottini, Weisheng Guo,* and Xing-Jie Liang*. NVP-BEZ235/Chlorin-e6 Co-loaded Nanoparticles Ablate Breast Cancer by Biochemical and Photodynamic Synergistic Effects, Nano Res, 2018, 11 (9), 4846-4868.

33. Hesham R. El-Seedi, Rehan M. El-Shabasy, Shaden A. M. Khalifa, Aamer Saeed, Afzal Shah, Raza Shah, Faiza Jan Iftikhar, Xiaobo Zou, Mohammed F. Halabi, Wessam Sarhan and Weisheng Guo*. Metal nanoparticles fabricated by green chemistry using natural extracts: biosynthesis, mechanisms, and applications, RSC Advances, 2019, 9, 24539-24559.

34. Weisheng Guo, Weitao Yang, Yu Wang, Xiaolian Sun, Zhongyun Liu, Bingbo Zhang, Jin Chang,* and Xiaoyuan Chen*. Color-tunable Gd-Zn-Cu-in-S/ZnS quantum dots for dual modality magnetic resonance and fluorescence imaging, Nano Research, 2014, 7(11): 1581-1591.

35. Weisheng Guo, Na chen, Yu Tu, Chunhong Dong, Bingbo Zhang,^* Chunhong Hu, and Jin Chan^*. Synthesis of Zn-Cu-In-S/ZnS core/shell quantum dots with inhibited blue-shift photoluminescence and applications for tumor targeted bioimaging, Theranostics, 2013, 3(2): 99-108.

36. Weisheng Guo, Yao Peng & Jin Chang*. Synthesis of pH-sensitive endosomolytic histidine-grafted poly (β-amino ester)s for gene delivery, Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 12(2): 559.

37. Tingbin Zhang,^# Weisheng Guo,^# Chunqiu Zhang, Jing Yu, Jing Xu, Shuyi Li, Jian-Hua Tian, Paul C. Wang, Jin-Feng Xing,* and Xing-Jie Liang*. Transferrin Dressed Virus-like Ternary Nanoparticles with Aggregation Induced Emission for Targeted Delivery and Rapid Cytosolic Release of siRNA, ACS Appl. Mater. Interfaces, 2017, 9 (19), 16006.

38. Weisheng Guo, Na Chen, Chunhong Dong, Yu Tu, Jin Chang,^* and Bingbo Zhang^*. One-pot synthesis of hydrophilic ZnCuInS/ZnS quantum dots for in vivo imaging, RSC Advances, 2013, 3(24): 9470-9475.

39. Weitao Yang,^# Weisheng Guo,^# Jin Chang,* Bingbo Zhang*. Protein/peptide-templated biomimetic synthesis of inorganic nanoparticles for biomedical applications, Journal of Materials Chemistry B, 2017, 5, 401.

40. Chukwunweike I. Okeke, Ahmed S. Eltahan, Tingbin Zhang, Jing Chen, Yingze Wang, Meng-Qi Xu, Lu Liu, An-Qi Yang, Weisheng Guo∗, and Xing-Jie Liang∗. Co-Delivery of Itraconazole and Docetaxel by Core/Shell Lipid Nanocells for Systemic Antiangiogenesis and Tumor Growth Inhibition, Journal of Biomedical Nanotechnology, 2017, 13, 1-15.

41. Tingbin Zhang, Qian Zhang, Jian-Hua Tian, Jin-Feng Xing, Weisheng Guo*, and Xing-Jie Liang*. Perfluorocarbons-based nanomedicine: emerging strategy for diagnosis and treatment of diseases, MRS Communications, 2018, 8(2), 303-313.

42. Pingsheng Huang,^# Weisheng Guo,^# Guang Yang, Huijuan Song, Yuqing Wang, Chun Wang, Deling Kong,* and Weiwei Wang*. Fluorine Meets Amine: Reducing Microenvironment-Induced Amino-Activatable Nanoprobes for 19F-Magnetic Resonance Imaging of Biothiols, ACS Appl. Mater. Interfaces, 2018, 10(22), 18532-18542.

43. Yingyi Yao,^# Weisheng Guo,^# Jian Zhang, Yudong Wu, Weihua Fu, Tingting Liu, Xiaoli Wu, Hanjie Wang, Xiaoqun Gong,* Xing-jie Liang, Jin Chang*. Reverse Fluorescence Enhancement and Colorimetric Bimodal Signal Readout Immunochromatography Test Strip for Ultrasensitive Large-Scale Screening and Postoperative Monitoring, ACS Appl. Mater. Interfaces, 2016, 8, 22963-22970.（IF=8.1，共同一作）

44. Yuhua Weng, Juan Liu, Shubin Jin, Weisheng Guo,* Xing-Jie Liang,* and Zhongbo Hu*. Nanotechnology-based strategies for treatment of ocular disease, Acta Pharmaceutica Sinica B, 2017, 7(3), 281-291.

45. Weitao Yang,^# Weisheng Guo,^# Xiaoqun Gong, Bingbo Zhang,* Sheng Wang, Na Chen, Wentao Yang, Yu Tu, Xiangming Fang, and Jin Chang*. Facile Synthesis of Gd–Cu–In–S/ZnS Bimodal Quantum Dots with Optimized Properties for Tumor Targeted Fluorescence/MR In Vivo Imaging, ACS Appl Mater Inter, 2015, 7(33): 18759-18768.

46. Wentao Yang,^# Weisheng Guo,^# Tingbin Zhang, Weitao Yang, Lin Su, Lei Fang, Hanjie Wang, Xiaoqun Gong,* and Jin Chang*. Synthesis of aqueous AgInS/ZnS@ PEI as a self-indicating nonviral vector for plasmid DNA self-tracking delivery, Journal of Materials Chemistry B, 2015, 3(43): 8518-8527.

授权专利

1. 常津(导师)，郭伟圣，水溶性闪锌矿结构的CuInS和CuInS/ZnS核壳结构量子点制备方法。（已授权）