个人概况：
姓名：杜雯 性别：女
职称：教授 导师资格：硕士导师
单位：广州医科大学生物医学工程学院
学历：博士 毕业院校：中国科学院生物物理研究所
招生专业：生物医学工程
电子邮件：duwen@gzhmu.edu.cn
通信地址：广州医科大学番禺校区A1-506
研究方向：
1. 呼吸系统疾病相关的干细胞诱导分化
2. 肠道类器官
3. 糖尿病发展过程中胰岛β细胞衰竭的分子机制
主持科研/教学项目：
1. 广州医科大学“南山学者”高层次人才启动经费（200万，主持，在研）；
2. 国家自然科学基金青年项目（314004000，25w，主持，结题）；
部分代表性第一和通讯作者论文：
1. Du W, Wang J, Kuo T, Wang L, McKimpson MW, Son J, Watanabe H, Kitamoto T, Lee Y, Ratner EL, McCune K, Chen Y, Grubbs HB, Thornton EM, Fan J, Sultana N, Diaz B, Balasubramanian I, Gao N, Belvedere S, Accili D. Pharmacological conversion of gut epithelial cells into insulin-producing cells lowers glycemia in diabetic animals. J Clin Invest. 2022 Dec 15;132(24):e162720. doi: 10.1172/JCI162720.
2. Lee Y*, Du W*, Nie Y*, Diaz B, Sultana N, Kitamoto T, Leibel R, Accili D, Belvedere S. Single-agent FOXO1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic mice. Mol Metab, 2022 Dec;66:101618. doi: 10.1016/j.molmet.2022.101618. (*co-first authors)
3. Fan J*, Du W*, Kim-Muller JY, Son J, Kuo T, Larrea D, Garcia C, Kitamoto T, Kraakman MJ, Owusu-Ansah E, Cirulli V, Accili D. Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with β-cell failure. Mol Metab. 2020 Apr; 34: 97-111. (*co-first authors)
4. Du W*, Zhou M*, Zhao W*, Cheng D, Wang L, Lu J, Song E, Feng W, Xue Y, Xu P, Xu T. HID-1 is required for homotypic fusion of immature secretory granules during maturation. Elife. 2016 Oct 18; 5. (*co-first authors)
5. Liang K*, Du W*, Lu J, Li F, Yang L, Xue Y, Hille B, Chen L. Alterations of the Ca²⁺ signaling pathway in pancreatic beta-cells isolated from db/db mice. Protein Cell. 2014 Oct; 5(10):783-94. (*co-first authors)
6. Du W, Xue Y, Liang K, Yuan T, Lu J, Zhao W, Xu T, Chen L Bulk-like endocytosis plays an important role in the recycling of insulin granules in pancreatic beta cells. Protein Cell. 2012 Aug; 3(8):618-26.
7. Liang K*,Du W*, Zhu W*, Liu S, Cui Y, Sun H, Luo B, Xue Y, Yang L, Chen L, Li F. Contribution of different mechanisms to pancreatic beta-cell hyper-secretion in NOD mice during pre-diabetes. J Biol Chem. 2011 Sep 13. (*co-first authors)
