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张建

发布时间:2022-06-06 浏览次数:

个人概况

姓名:张建    性别:

职称:教授    导师资格:硕士/博士生导师

单位:广州医科大学生物医学工程学院

学历:博士       毕业院校:华南师范大学

招生专业:生物医学工程、生物与医药

电子邮件:jianzhang@gzhmu.edu.cn

通信地址:广州市番禺区新造镇广州医科大学番禺校区

 

研究方向

1生物医学成像,基于光声成像光学相干成像,开展心脑血管疾病、脑神经疾病和癌症等疾病研究。

2、生物医学仪器研发,面向临床重大需求,根据相关的研究成果,开发新的成像方法和成像装置。

3、多功能纳米材料开发及应用,开发增强型造影剂应用于光声成像和光学相干成像,靶向型造影剂用于分子成像。


所获奖项/荣誉

12014年王大珩高校学生光学奖

22016年中国光学重要成果


指导学生获得的科研项目和奖项

12017年全国基础医学创新暨实验设计大赛,三等奖

22019年广东省“挑战杯”,一等奖

32020年广东省“挑战杯”,银奖

42020年广东省“电子竞赛”,二等奖


社会兼职

1、中国医学装备协会超声装备技术分会超声换能器及材料专委会常务委员

2、中国生物医学工程学会生物医学光子学分委会青年委员

3、中国光学学会生物医学光子学氛分委会高级会员

4、广东省机械工程学会摩擦学分会理事

5、中国生物医学工程学会高级会员

6、广东省生物物理学会理事

7、广东省科技厅科技特派员


主持科研/教学项目

1、国家自然科学基金青年项目(11704082),一种基于光吸收散射成像活体表征斑马鱼大脑的新方法及其在阿尔兹海默病应用基础研究,30万元,结题。

2、广东省自然科学基金面上项目(2020A1515011104),牙硬组织铒激光消融后表面变性层快速定量评估方法的研究,10万,在研。

3、广州市科创委项目(202102020140),OCT高分辨率活体表征骨质疏松斑马鱼模型新方,5万,在研。


部分代表性第一和通讯作者论文

1Zhang, J., Yang, S., Ji, X., Zhou, Q., & Xing, D.*, "Characterization of lipid-rich aortic plaques by intravascular photoacoustic tomography: ex vivo and in vivo validation in a rabbit atherosclerosis model with histologic correlation," Journal of the American College of Cardiology 2014,64, 385-390.

2Zhang, J., Ge, W., & Yuan, Z.*, "In vivo three-dimensional characterization of the adult zebrafish brain using a 1325 nm spectral-domain optical coherence tomography system with the 27 frame/s video rate," Biomedical Optics Express 2015, 6, 3932-3940.

3Zhang, J., Zhang, Z. W., Ge, W., & Yuan, Z.*, "Long-term in vivo monitoring of injury induced brain regeneration of the adult zebrafish by using spectral domain optical coherence tomography," Chinese Optics Letters 2016, 14(8): 081702.

4Zhang, J., Chen, H., Zhou, T., Wang, L., Gao, D., Zhang, X., ... & Yuan, Z.*, "A PIID-DTBT based semi-conducting polymer dots with broad and strong optical absorption in the visible-light region: Highly effective contrast agents for multiscale and multi-spectral photoacoustic imaging" Nano Research. 2017, 10(1): 64-76.

5Zhang, J., Pun, S. H., Yu, Y., Gao, D., Wang, J., Mak, P. U., ... & Yuan, Z.*,"Development of a multi-band photoacoustic tomography imaging system based on a capacitive micromachined ultrasonic transducer array.” Applied Optics, 2017, 56(14): 4012-4018.

6 Lin Y, Xiang X, Chen T, & Zhang, J*. In vivo monitoring and high-resolution characterizing of the prednisolone-induced osteoporotic process on adult zebrafish by optical coherence tomography. Biomedical Optics Express, 2019, 10(3): 1184-1195.

7Lin, Y., Xiang, X., Chen, T., Mao, G., Deng, L., Zeng, L., & Zhang, J*.In vivo monitoring the dynamic process of acute retinal hemorrhage and repair in zebrafish with spectraldomain optical coherence tomography. Journal of Biophotonics, 2020, e201900235.

8 Huang, W., Gao, C., Lan, Y., Zeng, S., Pathak, J. L., Zhou, M., ... & Zhang, J*. Optical coherence tomography characterizes the roughness and thickness of the heterogeneous layer on cortical bone surface induced by Er: YAG laser ablation at different moisture contents. Quantitative Imaging in Medicine and Surgery, 2020, 10(3), 713.

9Zhang, J., Qiu, T., Lan, Y., Tu, C., Shang, T., Lin, Y., ... & Yang, B. "Autocatalytic polymerization of selenium/polypyrrole nanocomposites as functional theranostic agents for multi-spectral photoacoustic imaging and photothermal therapy of tumor." Materials Today Chemistry, 2020, 17: 100344.

10Qiu T, Lan Y, Wei Z, Zhang Y, Lin Y, Tu C, Mao G, Zhang L, Yang B, Zhang J*. In vivo Multi-scale Photoacoustic Imaging Guided Photothermal Therapy of Cervical Cancer based on Customized Laser System and Targeted Nanoparticles. International Journal of Nanomedicine. 2021;16:2879-2896.

11Zeng, S., Liu, S., Lan, Y., Qiu, T., Zhou, M., Gao, W., ... & Zhang J*. (2021). Combined Photothermotherapy and Chemotherapy of Oral Squamous Cell Carcinoma Guided by Multifunctional Nanomaterials Enhanced Photoacoustic Tomography. International journal of nanomedicine, 16, 7373.

12Xiang X, Gao W, Xu Y, et al. Zhang J.* Study on promoting regeneration of zebrafish skull by phycocyanin characterized by in vivo optical coherence tomography. Journal of Biophotonics, 2022: e202100333.


授权专利

1、基于光谱编码的光声组分解析成像方法及装置,发明专利号:ZL 201010571641.4

2、聚焦式旋转扫描光声超声血管内窥成像装置及其成像方法,发明专利号ZL 201210220399.5

3、一种用于组织光谱检测的手持式光纤探头,实用新型专利:CN201921938184.0

4、一种基于光腔衰荡光谱的呼出气血糖检测装置,实用新型专利:CN201922068689.2

5、基于拉曼光谱和OCT测定玻璃材料性质的系统与方法,发明专利 CN201811059464.4

6、一种基于精密滑台的五轴斑马鱼脑立体定位仪,发明专利 CN201911069086.2



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