主持市级及以上科研/教学项目 |
|
2025.01-2027.12 |
|
|
国家自然科学基金青年基金：丙酮酸激酶PKM在人多能干细胞分化胰岛beta细胞功能成熟的作用和调控机制研究，经费：30万。（主持） |
|
|
|
近五年部分第一和通讯作者论文 |
[1] Haopeng Lin, Xin Liu, Lihua Chen, Yanying Guo, Tao Xu, Huisheng Liu*, Glucose Metabolism and Regulation in Establishing Human Stem Cell-Derived β Cell Maturation. Cell Reports, 2025. （中科院大类1区，IF=8.5） |
[2] Haopeng Lin, Kunimasa Suzuki, Nancy Smith, Xi Li, Lisa Nalbach, Sonia Fuentes, Aliya F. Spigelman Patrick E MacDonald* et al, A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding. Nature Communications, 2024. （中科院大类1区，IF=16.1）
|
[3] Haopeng Lin, Nancy Smith, Aliya F. Spigelman, Kunimasa Suzuki, Mourad Ferdaoussi, Tamadher A. Alghamdi, Sophie L. Lewandowski, Patrick E MacDonald* et al, β-cell knockout of senp1 reduces responses to incretins and worsens oral glucose tolerance in high-fat diet–fed mice. Diabetes, 2021. (中科院大类1区，IF=7.1）
|
[4] Haopeng Lin, Deqi Chen, Feng Zhang, Xin Liu, Xiaoxiao Xie, Qifei Dong, Jiawei Yan, Jiaxiang Yin, Zirong Bi, Kuo Jiang, Tongran Zhang, Peng Xue, Wei Peng, Lihua Chen, Tao Xu, Yanying Guo, Zonghong Li, Huisheng Liu*, Restoration of PKM1 improves functional maturation of human stem-cell derived-β cell by regulating PEP metabolism. Biorxiv. 2025. (Revision and Resubmitted to Nature communications)
|
[5] Xin Liu, Feng Zhang, Deqi Chen, Jiaxiang Yin, Zirong Bi, Lihua Chen, Jiawei Yan, Qifei Dong, Wei Peng, Tao Xu, Yanying Guo, Haopeng Lin*, Huisheng Liu*, Generation of INS-jGCaMP7f knock-in Ca2+ reporter human embryonic stem cell line, GZLe001-C, using CRISPR/Cas9-based gene targeting. Stem Cell Research, 2025.
|
